But my hunch is, youd know better than me, is that for things like influenza, we actually dont even know the answer, even though weve had 100 years to be thinking about that. LEVITT: So, tell me what are your current feelings towards sugar? Its great to live until youre 90 or 100 years old, but if you spend the last 20 or 30 years in so much pain or with a neurodegenerative disease like Alzheimers, youre not really enjoying those last few decades. But the probability, Steve, that you or I may get the rest of our lives without another pandemic must be viewed as exceedingly small. Non-lame, weekly emails on thelatest strategies and tacticsfor increasing your lifespan, healthspan, and well-being (plus new podcast announcements). That sort of irked me. It promises to be one of the most important books you'll ever read." Steven D. Levitt, New York Times bestselling author of Freakonomics "In Outlive, Peter Attia explores the science of not just . Well, I have six kids and I havent had a good nights sleep in 18 years. What the three main pieces of our healthspan are. ATTIA: I think without a step-function change in our technology and our understanding of science, it probably depends on how bad they are to begin with. Right? So, Ive done a lot of different things and that makes me a master of nothing. Incredible evidence in how it prevents neurodegeneration and basically all forms of chronic disease. funding for the rest of your life.. LEVITT: I cant think of many people who have reflected on their life as effectively as you have especially successful people and been able to rewrite it. According to his website, Attia is "a Stanford/Johns Hopkins/NIH-trained physician focusing on the applied science of longevity, the extension of human life and well-being." These credentials have given Attia unparalleled clout (along with David Sinclair) in this niche of influencers. And you said, Well, Im allergic to sugar. And with a great deal of curiosity, she said, What happens to you when you eat sugar? And you looked at her completely deadpan. And lets be honest. Hes really it makes me hopeful that I got some of those genes, that I can have a shot at some of that too. ATTIA: I mean, look, Steve, that is a million dollar question. Dr. Peter says there are four main ways to do it. To listen ad-free, subscribe to Stitcher Premium. In 2014, Attia founded Attia Medical, PC, a medical practice focusing on the applied science of longevity and optimal performance. ATTIA: No. And more recently, and that is to say in the last hundred years or so, people figured out that you could basically trick your body into doing that by restricting carbohydrates. I definitely had one horrible concussion. To listen ad-free, subscribe to Stitcher Premium. But there was a brutal concussion I had. Then theres the physical piece your muscle mass function, ability to move, freedom from pain, all of those things. Part of the practice includes nutritional biochemistry, a field that deals with supplements. All of the music you heard on this show was composed by Luis Guerra. Marion Nestle notes the Arnold's working relationship with a National Restaurant Association and the National Cattlemen's Beef Association consultant. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply. scan a couple days later. However, theres one disease that underlies all three of these. I hope you loved this episode as much as I did. And that, to me, is where I get shocked at what Id call the failure of medicine in this dimension to provide us with the answers that, if we had known a lot more about other kinds of infectious diseases, we probably could have been a lot smarter. LEVITT: And I asked you, Well, how do you know when its time to stop working out? You said, Either when I lose consciousness or when I piss or crap myself, thats when I decide Ive worked out hard enough.. Theres days when I think technologys going to solve all of our problems. Matt Hickey is the producer, and Dan Dzula was the engineer of this episode. Whats so good about being in ketosis? I think its worth understanding that a little bit. It showed I had cerebral contusions. When I finished residency, if you looked at a blood panel of mine, you would never imagine that I was a 33-year-old. So the former is one molecule of something called glucose and one of fructose bound together. I also had an additional conversation with Kevin Hall, PhD, one of the key researchers NuSI . And then, of course, this third piece, which is the emotional resilience and the ability to maintain a tolerance around distress. , Most people, when they think of death, think of what we call cardiopulmonary death or what Im calling death-certificate death. But probably 80% of people have actually died one of the other deaths before they die a cardiopulmonary death. As we get older, we may develop knee or hip problems, hearing or vision loss, or even memory problems. 2 teaspoons (10 mL) every evening with dinner, providing 1600mg EPA and 1,000mg DHA. Donate here: DID THE DIETARY GUIDELINES (AND LOW-FAT DIETS, SUGAR, ETC.) So, if we can stop eating a few hours before bedtime, well get better sleep, our bodies will process the glucose we consume, and we can avoid Type 2 diabetes. Im involved in a coronavirus study now, that were trying to get off the ground, thats looking at the long term impact of immunity. He attended Stanford University School of Medicine, where he received his M.D. This episode is informative, and I know youll get a lot of value from it. We can be reached at radio@freakonomics.com. They have to basically show every year that theres an R.O.I. But a quick 20-minute power nap is no big deal! is part of the Freakonomics Radio Network, and is produced by, and Stitcher. LEVITT: And then you became obsessed with nutrition. So taking a bunch of people who have recovered and asking the question: what does their recovery tell us about their risk of subsequent infection relative to uninfected people? Dr. Peters goal is to reduce those early deaths as much as possible. And I had all the time in the world. And we differentiate that form from the one that we evolved with by calling it nutritional ketosis. Prior to that, in 1996, he received a Bachelor of Science degree in Mechanical Engineering and Applied Mathematics from Queen's University. And I felt great. The four huge factors of Type 2 Diabetes. He has since been mentored by some of the most experienced and innovative lipidologists, endocrinologists, gynecologists, sleep physiologists, and longevity scientists in the United States and Canada. Also, I had a big fight with one of the physicians at Hopkins whos super respected and amazingly prominent. But it could put a slightly different interpretation on it. Weve developed treatments for all kinds of conditions from acne to cancer, and weve greatly expanded our lifespans. If you want pasta sauce, find one that has no sugar. TheDriveis hosted by Dr. Peter Attia, a Stanford/Johns Hopkins/NIH-trained physician focusing on the applied science of longevity, the extension of human life, and well-being. Whats the latest we should eat before going to bed? He is the host ofThe Drive, one of the most popular podcasts covering the topics of health and medicine. And to me, we want to minimize that gap, right? So I know Ive got the time to get better and better. But you started out wanting to be a professional boxer. And to me, we want to minimize that gap, right? ATTIA: Ive come a long way since then, Steve. ATTIA: Yeah, but you have to remember, I mean, the N.I.H. We won. And even if there were such data, what data are there that this harm is caused by the glucose itself? Now to your question, I did at one point in my life, circa 2011 to 2014, spend three years in uninterrupted nutritional ketosis. All of the music you heard on this show was composed by Luis Guerra. I think nicotine is a remarkable molecule. What happened to @DMSabatini. But I get a little bit worried that I dont know how to prepare them for a world that I dont understand. So thats called starvation ketosis. Throughout our lives, we experience different stressors that can cause strain on our mental health. Its our inability to get smarter as we went along. Wouldnt you like to live longer? The biggest risk, by the way, is probably mass vaccination. It also impairs senescent cells or more likely impairs the secreting factors that are made by senescent cells. But to accomplish that goal, we have to learn how to prevent chronic diseases. For all its successes, mainstream medicine has failed to make much progress against the diseases of aging that kill most people: heart disease, cancer, Alzheimers disease, and type 2 diabetes. The four pillars of being a kick-ass 100-year-old. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Available for pre-order everywhere books are sold. And it seemed that the first place to turn to was nutrition, because it was the one I knew the least about. But it also comes with letting go of a bunch of stuff, too. He is the Co-founder and Chief Medical Officer of the fasting app. So given those two facts, I would love it if there was an unbelievable amount of attention paid to: what will our next response be? LEVITT: And it sounds like youre doing it all with private money. 15. And honestly, one of the least predictable and most intelligent people Ive ever met. Poor, poor waitress. HOMA-IR and frailty (same study as #3 linked twice); The studies that use OGTT do not establish that glucose variability above 140 mg/dL is important; None show that the high glucose itself is causal or that reducing it via diet will improve outcomes. LEVITT: And so why? His post can be found here. Lets watch this thing instead. And shes like, Who is this guy? And I said, Look, I dont agree with half the things this guy says, but he is categorically one of the smartest dudes ever. And actually, my model ended up working really well, but I was basically threatened that Id be fired if I ever did it again. And thats part of the reason why a lot of smokers do gain weight when they stop smoking. Where did this insecurity come from? And so I do I think death is a very important part of the carbon cycle. So what are some things we can do to improve our sleep to keep this from happening? In addition to training at Johns Hopkins Hospital, Dr. Peter also spent two years at the National Institutes of Health as a surgical oncology fellow at the National Cancer Institute, where his research focused on immune-based therapies for melanoma. Those are the three biggest causes of death heart disease, cancer, and Alzheimers. Try playing chess with it, its so confident gives you a very detailed analysis why it's making a move and why your move was wrong, but tried to make illegal moves and doesn't One half of all Americans are on that spectrum. Dr. Peter Attia. LEVITT: So tell me about when you were 14 and you wanted to be a professional boxer. The purpose of comments on our site is to expand knowledge, engage in thoughtful discussion, and learn more from readers. And in the end, it was true that I was no more tired than I was in general, but I completely lost my will to live. Its also the one that seemed the most conflicted. [1] [2] He is also the first person to make the round-trip swim from Maui and Lanai. Bring everyone together in one space with Microsoft Teams! [3], Peter Attia was born on 19 March 1973 in Toronto, Ontario, Canada. for Dr. Peters definition of greatness, so for now, Ill leave you with one final piece of wisdom: There are people out there who have so many genetic things working against them, that theyll be lucky to make it to 80. And then after school, I would get home and then do another 90 minutes of work on the heavy bag, speed bag, double end bag in my basement, coupled with more anaerobic training. It is the one thing that makes all three of those worse, and, in its most extreme state, its Type 2 diabetes. Because for most people, the last 20 years, especially the last 10 years, are not great, both physically and cognitively. And I hope thats the kind of lesson that I can reinforce, which is: youve got to become a good thinker. But something inside said, You dont feel right. So I said, Hey, Mike, I got to call it a day, man. And when I went down to cool down by hitting the speed bag, which is that tiny little round bag that basically has no weight or impact just the impact of hitting that hurt my head so much that I was like, I got to stop.. Hes one of the most intelligent, curious, compassionate people Ive ever met. Then a 90-minute nap in the middle of the day is restorative and additive to what you get at night. What outcome data are there to show that going above 140 mg/dL in a normal glucose excursion is harmful? But I tried to build a mathematical model to address a problem in the I.C.U. Most people, when they think of death, think of what we call cardiopulmonary death or what Im calling death-certificate death. But probably 80% of people have actually died one of the other deaths before they die a cardiopulmonary death. Workout and Diet. Your podcasts are like a massive gift to humanity. And you were like, Whats that? And I was like, Oh, I chew Nicorette gum. And you asked me if I was a smoker. If you learned something today, please share it with us! ATTIA: So there were a lot of things that were really upsetting me at the time. So maybe some combination of those two things would be helpful as a person navigates their way. And they have totally different mechanisms. Its also that it has no fiber left in it as well. Steve LEVITT: It is such a pleasure to be talking today with my good friend Peter Attia, physician, endurance athlete, longevity expert, podcaster. Peter Attia (born 19 March 1973) is a Canadian-American physician known for his medical practice that focuses on the science of longevity. Now he's a physician focused on the science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease) while simultaneously improving healthspan (quality of life). Peter Attia talks with Steve Levitt about the problem with immortality, what's missing from our Covid response, and why nicotine is underrated. Thats actually a billion dollar question. If you want bread, eat the bread that has no sugar. And you would say, Peter, those seem really easy, and youd be right as a 37-year-old stud, but the point is most 60 year olds couldnt do them. Dr. Peter Attia. When it comes to chronic and life-threatening diseases, Dr. Peter said it comes down to three major things: So the big three are, in order, atherosclerotic disease so thats vascular disease, meaning heart disease and stroke. But theres a lot of new research coming out among economists, of all people, thats starting to flag the importance of sleep. So you have this starvation ketosis, nutritional ketosis. Airplane versus subway? Dr. Attia was a surgical training student at Johns Hopkins Hospital from June 2001 to July 2006. So that comes in mostly two forms in the United States, which is sucrose, or table sugar, which is that white granular powder, or high fructose corn syrup, which is a syrupy liquid approximation of that. And youll tell me your latest thing. And then youd just be guaranteed to get N.S.F. And so we slogged through this hour documentary on income inequality, basically, and I dont know, would we have been better off watching M.S.T. Healthspan has three pieces, right? document.getElementById( "ak_js_3" ).setAttribute( "value", ( new Date() ).getTime() ); This field is for validation purposes and should be left unchanged. Its the cognitive piece so how well does your brain work as you age? is incredibly risk averse. Attia speaks at the Ancestral Health Symposium in 2013, "A Manhattan Project To End The Obesity Epidemic", "Is it what we eat? [4] First wanting to become a professional boxer, he later attended Queen's University, receiving B.Sc. The first two are simple: Diet and exercise. So we evolved this way to instead break down fat, which even under the leanest times, you still had days, if not months worth of energy from, because fat is so energy-dense, and we could turn that fat into a molecule called a ketone. And again fortunately, Olivias my oldest and shes 11. How often? In this operating manual for longevity, Dr. Peter Attia draws on the latest science to deliver innovative nutritional interventions, techniques for optimizing exercise and sleep, and tools for addressing emotional and mental health. Explore the list of the most recommended book titles suggested by Peter Attia . LEVITT: So the goal was that you wanted immediate feedback on what was going on inside your body as you did these extreme workouts that you were prone to do. But Im not the person thats actually going to do these studies. Everything was metabolically broken. And then I would go to the gym and do an hour workout before that was mostly rowing machine and skipping. Autophagy is, as its name implies auto is self, phagy is eating so its when these cells eat themselves. You have to have a second project which youve actually done, but you pretend that you havent done it. About Community. But the point is, without making these proactive changes, they mightve lived only until 70. Comments that attack an individual directly will be deleted. Dr. Attia received his medical degree from the Stanford University School of Medicine and trained for five years at the Johns Hopkins Hospital in general surgery, where he was the recipient of several prestigious awards, including resident of the year. 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